Is it true that the drugs produced by American pharmaceutical companies have fostered a foreign, often illegal, drug counterfeit business and substandard or counterfeit drugs? Can such a global epidemic that involves over 124 countries be placed on the doorstep of Big Pharma? While the North American and European pharmaceutical sales make up “two-thirds of the entire world sales of pharmaceuticals”, it’s noteworthy that only one-fourth of falsified drug sales are made to citizens of these two continents. (1) This reflects that the other three-fourth of sales are to other countries. Unfortunately, the counterfeit drugs are far inferior and often are nothing more than a placebo. Economics is the leading reason people turn to unregulated pharmaceutical markets. The other is an act of desperation to find a silver bullet cure for diseases conventional medicine cannot cure. Unregulated markets are just as life-threatening as many diseases. An inside look at these counterfeit drug seller inventories reveals volumes of loose pills and broken-up packs of medications that are easily misidentified. Beyond these significant reasons why people should avoid such markets, potential customers should consider that non-regulation means that not only are the manufacturing practices up for grabs, there is no guarantee of proper handling and storing of the drugs. In fact, these factors could make the drugs either no longer viable or worse, dangerous to take.